Frampton has lived in London, New York (Westchester), Los Angeles, and Nashville. After the September 11, 2001 attacks, Frampton decided to become a United States citizen. He moved to Indian Hill, a suburb east of Cincinnati, Ohio, in June 2000, the birthplace of his wife Tina Elfers and the city in which they were married in 1996. They chose to live there to be closer to Tina's family. They still reside there today.
Frampton has been married three times. His wives have been: Mary Lovett (1971–1973), Barbara Gold (1983–1993) with whom he had two children, Jade and Julian, and Tina Elfers (January 13, 1996 – present) with whom he has one child, named Mia Frampton. Jade Frampton earned a degree in fashion merchandising from Kent State University in 2005.
Also in 2000, Frampton served as a technical advisor for Cameron Crowe's autobiographical film Almost Famous. He also appears briefly in the film as 'Reg', a road manager for Humble Pie, Frampton's real-life former band.